Background A factor leading to Alzheimer's Disease (AD), portrayed by peripheral insulin
resistance, is Type 2 diabetes mellitus (T2D). The likelihood of T2D cases would be at …

Abstract Phosphomannomutase 2 deficiency (PMM2-CDG), the most frequent congenital
disorder of glycosylation, is an autosomal recessive disease caused by biallelic pathogenic …

Body shape is a complex and plastic trait with a high impact on fish performance and
commercialization. Shape is particularly relevant in flatfish with highly asymmetric bodies. In …

Meniere Disease (MD) is a chronic inner ear disorder characterized by vertigo attacks,
sensorineural hearing loss, tinnitus, and aural fullness. Extensive evidence supporting the …

Background Schaaf-Yang syndrome (SYS) is caused by truncating mutations in MAGEL2,
mapping to the Prader-Willi region (15q11-q13), with an observed phenotype partially …

A wide range of approaches can be used to detect micro RNA (miRNA)–target gene pairs
(mTPs) from expression data, differing in the ways the gene and miRNA expression profiles …

Abstract PMM2-CDG (MIM# 212065), the most common congenital disorder of glycosylation,
is caused by the deficiency of phosphomannomutase 2 (PMM2). It is a multisystemic disease …

Growth performance is a complex genetic trait that interacts with several environmental
variables and life-history attributes, most notably sex and reproduction. Thus, unveiling the …

The diagnosis of Mendelian disorders has notably advanced with integration of whole
exome and genome sequencing (WES and WGS) in clinical practice. However, challenges …

Angiogenesis is essential for tumor growth and cancer metastasis. Identifying the molecular
pathways involved in this process is the first step in the rational design of new therapeutic …