TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact
cause of the disease is still not known although many scientists believe in the beta amyloid …

Triggering receptor expressed on myeloid cells-like 2 (TREML2) is a newly identified
susceptibility gene for Alzheimer's disease (AD). It encodes a microglial inflammation …

In this review, we focus on the emerging roles of microglia in the brain, with particular
attention to synaptic plasticity in health and disease. We present evidence that ramified …

Nasu-hakola disease (NHD) is a rare disease characterized by bone cysts and fractures,
frontal lobe syndrome, and progressive presenile dementia. NHD may be the prototype of …

Recent research has shown that the triggering receptor expressed on myeloid cells 2
(TREM2) in microglia is closely related to the pathogenesis of Alzheimer's disease (AD). The …

TREM2 (triggering receptor expressed on myeloid cells 2) gene variants were reported to
increase the risk of Alzheimer's disease (AD) and even other neurodegenerative diseases …

Alterations in Triggering Receptors Expressed on Myeloid cells (TREM-1/2) are bound to a
variety of infectious, sterile inflammatory, and degenerative conditions, ranging from …

In the central nervous system, the primary immune cells, the microglia, prevent pathogenic
invasion as the first line of defense. Microglial energy consumption is dependent on their …

Autophagy is a metabolically-central process that is crucial in diverse areas of cell
physiology. It ensures a fair balance between life and death molecular and cellular flows …