Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …

Lipid phosphoinositides are master signaling molecules in eukaryotic cells and key markers
of organelle identity. Because of these important roles, the kinases and phosphatases that …

The lipid kinase phosphatidylinositol 4 kinase III α (PI4KIIIα/PI4KA) is a master regulator of
the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a …

While rhythmic contractile behavior is commonly observed at the cellular cortex, the primary
focus has been on excitable or periodic events described by simple activator-delayed …

The type III Phosphatidylinositol 4-kinase alpha (PI4KA) is an essential lipid kinase that is a
master regulator of phosphoinositide signalling at the plasma membrane (PM). It produces …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP2) has been shown to be critical for the
endocytosis of G protein-coupled receptors (GPCRs). We have previously demonstrated that …

Ion channels are the second largest class of drug targets after G protein-coupled receptors.
In addition to well-recognized ones like voltage-gated Na/K/Ca channels in the heart and …

Insulin stimulates glucose transport in muscle and adipocytes. This is achieved by regulated
delivery of intracellular glucose transporter (GLUT4)-containing vesicles to the plasma …

Lipopolysaccharide (LPS)-induced signaling through Toll-like receptor 4 (TLR4) is mediated
by the plasma membrane lipid, phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P2] and its …

The dynamic addition and removal of long chain fatty acids modulates protein function and
localization. The alpha/beta hydrolase domain-containing (ABHD) 17 enzymes remove acyl …