IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international
collaborative efforts have led to important discoveries that have improved our understanding …

IgA nephropathy (IgAN) is the most common type of glomerulonephritis in Asia and the
Western world. In most patients, it follows an asymptomatic to oligosymptomatic course and …

Importance Although IgA nephropathy (IgAN) is the most common glomerulonephritis in the
world, there is no validated tool to predict disease progression. This limits patient-specific …

Background Change in albuminuria has strong biological plausibility as a surrogate
endpoint for progression of chronic kidney disease, but empirical evidence to support its …

Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …

Background The outcomes of immunosuppressive therapy, when added to supportive care,
in patients with IgA nephropathy are uncertain. Methods We conducted a multicenter, open …

Background Surrogate end points are needed to assess whether treatments are effective in
the early stages of CKD. GFR decline leads to kidney failure, but regulators have not …

IgA nephropathy (IgAN) is an important cause of ESKD for which there are no approved
therapies. A challenge for evaluating treatments for IgAN is the usual long time course for …

Most glomerulonephritides, even the more common types, are rare diseases. They are
nevertheless important since they frequently affect young people, often cannot be cured, and …

Recent years have brought notable progress in the field of IgA nephropathy. Here, we
highlight important new directions and latest developments, including successful discovery …