[HTML][HTML] The complex biology of aryl hydrocarbon receptor activation in cancer and beyond
The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network
that plays a critical role in various biological processes, including cellular metabolism …
that plays a critical role in various biological processes, including cellular metabolism …
Drug metabolism in the lungs: opportunities for optimising inhaled medicines
Z Enlo-Scott, E Bäckström, I Mudway… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction The lungs possess many xenobiotic metabolizing enzymes which influence the
pharmacokinetics and safety of inhaled medicines. Anticipating metabolism in the lungs …
pharmacokinetics and safety of inhaled medicines. Anticipating metabolism in the lungs …
DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes
Background Abnormal epigenetic marking is well documented in gene promoters of cancer
cells, but the study of distal regulatory siteshas lagged behind. We performed a systematic …
cells, but the study of distal regulatory siteshas lagged behind. We performed a systematic …
Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health
Background Tobacco smoking is a risk factor for multiple diseases, including cardiovascular
disease and diabetes. Many smoking-associated signals have been detected in the blood …
disease and diabetes. Many smoking-associated signals have been detected in the blood …
Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans
Cigarette smoking is an environmental risk factor for many chronic diseases, and disease
risk can often be managed by smoking control. Smoking can induce cellular and molecular …
risk can often be managed by smoking control. Smoking can induce cellular and molecular …
Association of neighborhood disadvantage in childhood with DNA methylation in young adulthood
Importance DNA methylation has been proposed as an epigenetic mechanism by which the
childhood neighborhood environment may have implications for the genome that …
childhood neighborhood environment may have implications for the genome that …
CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study
Background: Smoking increases the risk of many diseases, and it is also linked to blood
DNA methylation changes that may be important in disease etiology. Objectives: We sought …
DNA methylation changes that may be important in disease etiology. Objectives: We sought …
Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression
LJ Buro-Auriemma, J Salit, NR Hackett… - Human molecular …, 2013 - academic.oup.com
The small airway epithelium (SAE), the first site of smoking-induced lung pathology, exhibits
genome-wide changes in gene expression in response to cigarette smoking. Based on the …
genome-wide changes in gene expression in response to cigarette smoking. Based on the …
Epigenomics and interindividual differences in drug response
M Ivanov, M Kacevska… - Clinical Pharmacology …, 2012 - Wiley Online Library
Epigenomics is a rapidly growing field. New developments in epigenetics, such as the
recently described modified cytosine variants (eg, 5‐hydroxymethylcytosine, 5hmC) and an …
recently described modified cytosine variants (eg, 5‐hydroxymethylcytosine, 5hmC) and an …
AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1) by recruiting Sp1
W Ye, R Chen, X Chen, B Huang, R Lin, X Xie… - The FEBS …, 2019 - Wiley Online Library
Cytochrome P450 1A1 (CYP1A1) is abundant in the kidney, liver, and intestine and is
involved in the phase I metabolism of numerous endogenous and exogenous compounds …
involved in the phase I metabolism of numerous endogenous and exogenous compounds …