Breast cancer metastasis: mechanisms and therapeutic implications

M Park, D Kim, S Ko, A Kim, K Mo, H Yoon - International journal of …, 2022 - mdpi.com
Breast cancer is the most common malignancy in women worldwide. Metastasis is the
leading cause of high mortality in most cancers. Although predicting the early stage of breast …

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials

Y Cheng, C He, M Wang, X Ma, F Mo, S Yang… - Signal transduction and …, 2019 - nature.com
Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

A review of classification, biosynthesis, biological activities and potential applications of flavonoids

S Chen, X Wang, Y Cheng, H Gao, X Chen - Molecules, 2023 - mdpi.com
Flavonoids represent the main class of plant secondary metabolites and occur in the tissues
and organs of various plant species. In plants, flavonoids are involved in many biological …

DNA methyltransferases: a novel target for prevention and therapy

D Subramaniam, R Thombre, A Dhar, S Anant - Frontiers in oncology, 2014 - frontiersin.org
Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Botanicals and their bioactive phytochemicals for women's health

BM Dietz, A Hajirahimkhan, TL Dunlap, JL Bolton… - Pharmacological …, 2016 - Elsevier
Botanical dietary supplements are increasingly popular for women's health, particularly for
older women. The specific botanicals women take vary as a function of age. Younger …

The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Flavonoids and other polyphenols act as epigenetic modifiers in breast cancer

P Selvakumar, A Badgeley, P Murphy, H Anwar… - Nutrients, 2020 - mdpi.com
Breast cancer is a common cancer that occurs due to different epigenetic alterations and
genetic mutations. Various epidemiological studies have demonstrated an inverse …

[HTML][HTML] DNA methylation, its mediators and genome integrity

H Meng, Y Cao, J Qin, X Song, Q Zhang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms

D Sinha, N Sarkar, J Biswas, A Bishayee - Seminars in cancer biology, 2016 - Elsevier
Globally, breast cancer is the most frequently diagnosed cancer among women. The major
unresolved problems with metastatic breast cancer is recurrence after receiving objective …

DNMT1: A key drug target in triple-negative breast cancer

KK Wong - Seminars in cancer biology, 2021 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer.
Altered epigenetics regulation including DNA hypermethylation by DNA methyltransferase 1 …