International union of basic and clinical pharmacology CXIII: Nuclear receptor superfamily—Update 2023
The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …
gene network programs involved in a wide range of physiologic processes. This review will …
Bisphenols as environmental triggers of thyroid dysfunction: clues and evidence
Bisphenols (BPs), and especially bisphenol A (BPA), are known endocrine disruptors
(EDCs), capable of interfering with estrogen and androgen activities, as well as being …
(EDCs), capable of interfering with estrogen and androgen activities, as well as being …
[HTML][HTML] Disruption by stealth-Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals
Thyroid hormones (THs) are important regulators of growth, development, and homeostasis
of all vertebrates. There are many environmental contaminants that are known to disrupt TH …
of all vertebrates. There are many environmental contaminants that are known to disrupt TH …
2, 4-Di-tert-butylphenol induces adipogenesis in human mesenchymal stem cells by activating retinoid X receptors
XM Ren, RC Chang, Y Huang, A Amorim Amato… - …, 2023 - academic.oup.com
Di-tert-butylphenol (2, 4-DTBP) is an important commercial antioxidant and a toxic natural
secondary metabolite that has been detected in humans. However, there is scant …
secondary metabolite that has been detected in humans. However, there is scant …
A review of species differences in the control of, and response to, chemical-induced thyroid hormone perturbations leading to thyroid cancer
JR Foster, H Tinwell, S Melching-Kollmuss - Archives of Toxicology, 2021 - Springer
This review summarises the current state of knowledge regarding the physiology and control
of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and …
of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and …
Evolution of regulated transcription
The genomes of all organisms abound with various cis-regulatory elements, which control
gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and …
gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and …
Thyroid hormone and the white matter of the central nervous system: from development to repair
The role of thyroid hormone (TH) on brain development, and particularly in myelination, is
well known since many decades, as testified by the severe structural and functional …
well known since many decades, as testified by the severe structural and functional …
Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial …
L Nunes Santos, ÂM Sousa Costa, M Nikolov… - Communications …, 2024 - nature.com
Cardiac function requires appropriate proteins in each chamber. Atria requires slow myosin
to act as reservoirs, while ventricles demand fast myosin for swift pumping. Myosins are thus …
to act as reservoirs, while ventricles demand fast myosin for swift pumping. Myosins are thus …
BDE-99, but not BDE-47, is a transient aryl hydrocarbon receptor agonist in zebrafish liver cells
Polybrominated diphenyl ethers (PBDEs) are endocrine-disrupting chemicals that affect the
environment and the health of humans and wildlife. In this study, the zebrafish liver (ZFL) cell …
environment and the health of humans and wildlife. In this study, the zebrafish liver (ZFL) cell …
Truncated variants of thyroid hormone receptor beta display disease-inflicting malfunctioning at cellular level
Thyroid hormone receptor β (THRβ) is a member of the nuclear receptor superfamily of
ligand-modulated transcription factors. Upon ligand binding, THRβ sequentially recruits the …
ligand-modulated transcription factors. Upon ligand binding, THRβ sequentially recruits the …