Time for united action on depression: a Lancet–World Psychiatric Association Commission
Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …
in the way it becomes known to the self—to the mediating intellect—as to verge close to …
[PDF][PDF] The bidirectional relationship of depression and inflammation: double trouble
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …
Inflammatory processes have been implicated in the pathophysiology of depression. It is …
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in> 1.2 million individuals highlight new therapeutic directions
Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of
veterans. Here we report results of a large meta-analysis of depression using data from the …
veterans. Here we report results of a large meta-analysis of depression using data from the …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts
BackgroundThe COVID-19 pandemic and mitigation measures are likely to have a marked
effect on mental health. It is important to use longitudinal data to improve inferences. AimsTo …
effect on mental health. It is important to use longitudinal data to improve inferences. AimsTo …
[HTML][HTML] Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture
Genetic association studies have identified 44 common genome-wide significant risk loci for
late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction …
late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction …
[HTML][HTML] Single-cell epigenomics reveals mechanisms of human cortical development
During mammalian development, differences in chromatin state coincide with cellular
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …
differentiation and reflect changes in the gene regulatory landscape. In the developing brain …
[HTML][HTML] Genetic control of RNA splicing and its distinct role in complex trait variation
Most genetic variants identified from genome-wide association studies (GWAS) in humans
are noncoding, indicating their role in gene regulation. Previous studies have shown …
are noncoding, indicating their role in gene regulation. Previous studies have shown …
[HTML][HTML] Rare and common genetic determinants of metabolic individuality and their effects on human health
P Surendran, ID Stewart, VPW Au Yeung, M Pietzner… - Nature Medicine, 2022 - nature.com
Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …
molecular origins of human diseases. Untargeted high-throughput metabolomic …
[HTML][HTML] Polygenic risk scores: from research tools to clinical instruments
Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …
disorders have a polygenic genetic architecture and have enabled researchers to identify …