Group A Streptococcus (GAS; Streptococcus pyogenes) is a nearly ubiquitous human
pathogen responsible for a significant global disease burden. No vaccine exists, so …

Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory syndrome
associated with SARS-CoV-2 infection, shares clinical features with toxic shock syndrome …

Kawasaki disease (KD) is a pediatric vasculitis syndrome that is often involves coronary
artery lesions (eg, coronary artery aneurysms). Although its causal factors and entire …

Background With the establishment of the heart-gut axis concept, accumulating studies
suggest that the gut microbiome plays an important role in the pathogenesis of …

Background Streptococcus pyogenes (S. pyogenes) is a Gram positive bacterium which is a
leading cause of pharyngitis, skin and soft tissue infection and post streptococcal …

During the 1920s, acute rheumatic fever (ARF) was the leading cause of mortality in children
in the United States. By the 1980s, many felt ARF had all but disappeared from the US …

Background The concept that a minority of group A streptococcus (GAS) emm types are
more “rheumatogenic” than others has been widely disseminated. We aimed to provide a …

Summary Multisystem Inflammatory Syndrome in Children (MIS-C), a hyperinflammatory
syndrome associated with SARS-CoV-2 infection, shares many clinical features with toxic …

Chronic rhinosinusitis with nasal polyps (CRSwNP) has long been considered a benign,
chronic inflammatory, and hyperplastic disease. Recent studies have shown that …

Synthetic peptide vaccines based on epitopes derived from the conserved region of M-
protein are proving to be a realistic option for protection against group A streptococcus …