As the major cellular component of the innate immune system in the central nervous system
(CNS) and the first line of defense whenever injury or disease occurs, microglia play a …

Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Acute central nervous system (CNS) injuries, including stroke, traumatic brain injury (TBI),
and spinal cord injury (SCI), are the common causes of death or lifelong disabilities …

Age-related macular degeneration (AMD) is a significant cause of vision loss in the elderly.
The extent to which epigenetic changes regulate AMD progression is unclear. Here we …

Targeted protein degradation refers to the use of small molecules that recruit a ubiquitin
ligase to a target protein for ubiquitination and subsequent proteasome-dependent …

Current efficacious treatments for traumatic brain injury (TBI) are lacking. Establishment of a
protective gut microbiota population offers a compelling therapeutic avenue, as brain injury …

Neurotrophic factors (NTFs) are involved in the pathophysiology of neurological disorders
such as dementia, stroke and traumatic brain injury (TBI), and constitute molecular targets of …

Astrocyte activation is a hallmark of central nervous system injuries resulting in glial scar
formation (astrogliosis). The activation of astrocytes involves metabolic and morphological …

Neuroprotection is important in injuries of the CNS. Immediate damage from the injury may
not be reversible but the progression of the chain of events, which aggravate brain damage …