What is the role of the inflammation in the pathogenesis of heart failure?

EC Castillo, E Vázquez-Garza, D Yee-Trejo… - Current Cardiology …, 2020 - Springer
Abstract Purpose of Review In heart failure, whether it is associated with reduced or
preserved ejection fraction, the immune system is activated and contributes to heart …

Immunomodulation to prevent or treat neonatal sepsis: past, present, and future

SS Schüller, BW Kramer, E Villamor, A Spittler… - Frontiers in …, 2018 - frontiersin.org
Despite continued advances in neonatal medicine, sepsis remains a leading cause of death
worldwide in neonatal intensive care units. The clinical presentation of sepsis in neonates …

Pharmacological induction of autophagy reduces inflammation in macrophages by degrading immunoproteasome subunits

J Zhou, C Li, M Lu, G Jiang, S Chen, H Li, K Lu - Plos Biology, 2024 - journals.plos.org
Defective autophagy is linked to proinflammatory diseases. However, the mechanisms by
which autophagy limits inflammation remain elusive. Here, we found that the pan-FGFR …

Phosphodiesterase inhibitors in acute lung injury: what are the perspectives?

D Mokra, J Mokry - International Journal of Molecular Sciences, 2021 - mdpi.com
Despite progress in understanding the pathophysiology of acute lung damage, currently
approved treatment possibilities are limited to lung-protective ventilation, prone positioning …

Immunometabolic approaches to prevent, detect, and treat neonatal sepsis

MG Conti, A Angelidou, J Diray-Arce, KK Smolen… - Pediatric …, 2020 - nature.com
The first days of postnatal life are energetically demanding as metabolic functions change
dramatically to accommodate drastic environmental and physiologic transitions after birth. It …

Phosphodiesterase (1, 3 & 5) inhibitors attenuate diclofenac-induced acute kidney toxicity in rats

W Wadie, NS Abdel-Razek, HA Salem - Life sciences, 2021 - Elsevier
Diclofenac, one of the most commonly used non-steroidal anti-inflammatory drugs, leads to
severe adverse effects on the kidneys. The aim of the present study was to investigate the …

Salivary and Serum Interleukin‐10, C‐Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late‐Onset Neonatal Sepsis in Full‐Term …

A Omran, H Sobh, MO Abdalla… - Journal of …, 2021 - Wiley Online Library
Salivary markers could serve as potential noninvasive markers in the diagnosis of neonatal
infections. We aimed to investigate the diagnostic role of salivary and serum interleukin 10 …

Downregulation of miR‑1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS‑induced inflammatory response by inhibiting IL‑16 in monocytes

D Wang, L Han - Experimental and therapeutic …, 2021 - spandidos-publications.com
Neonatal sepsis (NS) remains a global problem. In the present study, abnormal expression
of microRNA‑1184 (miR‑1184) was detected in neonates with NS and it was endeavored to …

Protocol: Pentoxifylline optimal dose finding trial in preterm neonates with suspected late onset sepsis (PTX-trial)

S Kurul, HR Taal, RB Flint, J Mazela, IKM Reiss… - BMC pediatrics, 2021 - Springer
Background Late onset sepsis is a leading cause of death and morbidity in preterm infants.
Despite optimal antibiotic treatment, sepsis related mortality and morbidity is still high …

Expression and clinical significance of SATB1 and TLR4 in breast cancer

X Wang, X Yu, Q Wang, Y Lu… - Oncology letters, 2017 - spandidos-publications.com
This study investigated the expression of special AT‑rich sequence‑binding protein 1
(SATB1) and toll‑like receptor 4 (TLR4) protein in breast cancer and its clinical significance …