CD4 T cells play important roles in promoting protective immunity and autoimmune disease.
A great deal of attention has been given to the differentiation and function of subsets of …

Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour
cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on …

Graft versus host disease (GvHD) is the main complication of allogeneic hematopoietic stem
cell transplantation (HSCT). Here we report studies of a patient with chronic GvHD (cGvHD) …

The CD27–CD70 pathway is known to provide a costimulatory signal, with CD70 expressed
on APCs and CD27 functions on T cells. Although CD70 is also expressed on activated T …

Allogeneic hematopoietic transplantation (allo-HCT) is a curative therapy for a variety of
hematologic malignancies, primarily through immune-mediated clearance of malignant …

Transplantation of donor-derived allogeneic hematopoietic cells causes increased survival
in patients suffering from various blood cancers and other hematologic and immunologic …

CD4+ T cell activation and differentiation are important events that set the stage for proper
immune responses. Many factors are involved in the activation and differentiation of T cells …

Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment
for hematologic malignancies, and other hematologic and immunologic diseases. Donor …

The pivotal role of Granzyme B (GzmB) in immune responses, initially tied to cytotoxic T
lymphocytes (CTLs) and natural killer (NK) cells, has extended across diverse cell types and …

Allogeneic hematopoietic cell transplantation is a potential curative therapy for hematologic
malignancies. Host APCs are pivotal to the desired graft-versus-tumor (GVT) effect. Recent …