Structure-based drug design of RdRp inhibitors against SARS-CoV-2

K Shehzadi, A Saba, M Yu, J Liang - Topics in Current Chemistry, 2023 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human …

Antisense Therapy for Infectious Diseases

LA Buthelezi, S Pillay, NN Ntuli, L Gcanga, R Guler - Cells, 2023 - mdpi.com
Infectious diseases, particularly Tuberculosis (TB) caused by Mycobacterium tuberculosis,
pose a significant global health challenge, with 1.6 million reported deaths in 2021, making …

Proxalutamide reduces SARS-CoV-2 infection and associated inflammatory response

Y Qiao, JW Wotring, Y Zheng… - Proceedings of the …, 2023 - National Acad Sciences
Early in the COVID-19 pandemic, data suggested that males had a higher risk of developing
severe disease and that androgen deprivation therapy might be associated with protection …

Mechanisms of Action of the US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs

A Sang, S Zhuo, A Bochanis, JE Manautou, R Bahal… - BioDrugs, 2024 - Springer
Antisense oligonucleotides (ASOs) are single stranded nucleic acids that target RNA. The
US Food and Drug Administration has approved ASOs for several diseases. ASOs utilize …

Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA

M Yamasaki, W Saso, T Yamamoto, M Sato, H Takagi… - Antiviral Research, 2024 - Elsevier
Given the worldwide risk for the outbreak of emerging/re-emerging respiratory viruses,
establishment of new antiviral strategies is greatly demanded. In this study, we present a …

Polypurine reverse hoogsteen hairpins as a therapeutic tool for SARS-CoV-2 infection

S Valiuska, JM Rojas, P Nogales-Altozano… - Journal of Biological …, 2024 - jbc.org
Although the COVID-19 pandemic was declared no longer a global emergency by the World
Health Organization in May 2023, SARS-CoV-2 is still infecting people across the world …

[HTML][HTML] TMPRSS2-specific antisense oligonucleotides inhibit host cell entry of emerging viruses

R Nowak, M Gazecka, M Hoffmann, R Kierzek… - Virology, 2024 - Elsevier
Emerging viruses, such as novel influenza A viruses (IAV) and severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), pose a constant threat to animal and human health …

Decoding the genome of SARS-CoV-2: a pathway to drug development through translation inhibition

SN Wu, T Xiao, H Chen, XH Li - RNA biology, 2024 - Taylor & Francis
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the
coronavirus disease 2019 (COVID-19) pandemic and is continuously spreading globally …

[HTML][HTML] Viral RNA Interactome: The Ultimate Researcher's Guide to RNA–Protein Interactions

WA Hanson, GA Romero Agosto, S Rouskin - Viruses, 2024 - mdpi.com
RNA molecules in the cell are bound by a multitude of RNA-binding proteins (RBPs) with a
variety of regulatory consequences. Often, interactions with these RNA-binding proteins are …

Human angiotensin converting enzyme 2 specific antisense oligonucleotides reduce infection with SARS-CoV-2 variants

T Lu, C Zhang, Z Li, Y Wei, A Sadewasser… - Journal of Allergy and …, 2024 - Elsevier
Abstract Background The Spike protein mutation of SARS-CoV-2 led to decreased protective
effect of various vaccines and monoclonal antibodies, suggesting that blocking SARS-CoV-2 …