Brown adipose tissue-derived metabolites and their role in regulating metabolism

K Ziqubu, PV Dludla, SE Mabhida, BU Jack, S Keipert… - Metabolism, 2024 - Elsevier
The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treat obesity and metabolic diseases. Beyond its …

Uncoupling protein 1 does not produce heat without activation

Y Li, T Fromme - International Journal of Molecular Sciences, 2022 - mdpi.com
Mitochondrial uncoupling protein 1 (UCP1) is the crucial mechanistic component of heat
production in classical brown fat and the newly identified beige or brite fat. Thermogenesis …

Magnetic resonance imaging techniques for brown adipose tissue detection

M Wu, D Junker, RT Branca… - Frontiers in …, 2020 - frontiersin.org
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods
can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI …

Nutritional regulation of human brown adipose tissue

KJ Suchacki, RH Stimson - Nutrients, 2021 - mdpi.com
The recent identification of brown adipose tissue in adult humans offers a new strategy to
increase energy expenditure to treat obesity and associated metabolic disease. While white …

Magnetic resonance imaging of obesity and metabolic disorders: Summary from the 2019 ISMRM Workshop

HH Hu, RT Branca, D Hernando… - Magnetic resonance …, 2020 - Wiley Online Library
More than 100 attendees from Australia, Austria, Belgium, Canada, China, Germany, Hong
Kong, Indonesia, Japan, Malaysia, the Netherlands, the Philippines, Republic of Korea …

Repeatability of quantitative brown adipose tissue imaging metrics on positron emission tomography with 18F-fluorodeoxyglucose in humans

TJ Fraum, JP Crandall, DR Ludwig, S Chen, KJ Fowler… - Cell metabolism, 2019 - cell.com
Brown adipose tissue (BAT) is a promising target for anti-obesity interventions. This
prospective test-retest study assessed the repeatability of several important quantitative BAT …

[18F] FDG and [11C] PK11195 PET imaging in the evaluation of brown adipose tissue-effects of cold and pharmacological stimuli and their association with crotamine …

D de Paula Faria, JDA Campeiro… - Nuclear medicine and …, 2023 - Elsevier
This study aimed to evaluate the role of positron emission tomography (PET) with [11 C]
PK11195 and [18 F] FDG in the characterization of brown adipose tissue (BAT). Methods …

Activating Human Adipose Tissue with the β 3-Adrenergic Agonist Mirabegron

KY Chen, RJ Brychta, NS Israni, A Jiang… - Brown Adipose Tissue …, 2022 - Springer
An appealing strategy for treatment of metabolic disease in humans is activation of brown
adipose tissue (BAT), a thermogenic organ best visualized through 18F-FDG PET/CT. BAT …

18F-FDG PET/CT technology for the assessment of brown adipose tissue: an updated review

M Ricci, MS De Feo, GM Granese… - Expert Review of …, 2023 - Taylor & Francis
Introduction This review provides an update of 18 F-fluorodeoxyglucose ([18F] FDG) for
Brown adipose tissue (BAT) activity quantification, whose role is not completely understood …

Perspectives on brown adipose tissue imaging: insights from preclinical and clinical observations from the last and current century

JP Crandall, RL Wahl - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
Brown adipose tissue (BAT) was first described in the 16th century, but until late last century
had mainly been considered a tissue with the function of nonshivering thermogenesis …