Progress in the understanding of the biology of perinatal tissues has contributed to the
breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth …

While preclinical studies have reported improvement of behavioral deficits in the Ts65Dn
mouse model of Down syndrome (DS), translation to human clinical trials to improve …

The amnion membrane is developed from embryo-derived cells, and amniotic cells have
been shown to exhibit multidifferentiation potential. These cells represent a desirable source …

Axon regeneration is regulated by a neuron-intrinsic transcriptional program that is
suppressed during development but that can be reactivated following peripheral nerve …

Comparative studies of great apes provide a window into our evolutionary past, but the
extent and identity of cellular differences that emerged during hominin evolution remain …

Epigenetics, especially histone marks, functions beyond the DNA sequences to regulate
gene expression. Depletion of NSD1, which catalyzes H3K36me2, leads to both up-and …

The paired-like homeobox transcription factor LEUTX is expressed in human
preimplantation embryos between the 4-and 8-cell stages, and then silenced in somatic …

Although derivation of naïve bovine embryonic stem cells is unachieved, the possibility for
generation of bovine induced pluripotent stem cells (biPSCs) has been generally reported …

Quality control of induced pluripotent stem cells remains a challenge. For validation of the
pluripotent state, it is crucial to determine trilineage differentiation potential toward …

The potential for amniotic fluid stem cell (AFSC) treatment to inhibit the progression of fibrotic
lung injury has not been described. We have previously demonstrated that AFSC can …