Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …

Tumor cells must generate sufficient ATP and biosynthetic precursors in order to maintain
cell proliferation requirements. Otto Warburg showed that tumor cells uptake high amounts …

The evolutionary pressure for life transitioning from extended periods of hypoxia to an
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …

Human papillomavirus (HPV) is the most common sexually transmitted virus worldwide.
More than 99% of cervical cancer cases are associated with certain types of HPVs, termed …

The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …

Key pathological, including oncogenic, signaling pathways regulate the canonical functions
of metabolic enzymes that serve the cellular metabolic needs. Importantly, these signaling …

The growing field of tumor metabolism has greatly expanded our knowledge of metabolic
reprogramming in cancer. Apart from their established roles, various metabolic enzymes and …

Tissue sensitivity and response to exercise vary according to the time of day and alignment
of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not …

Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in
cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses …

Interleukin (IL)-2 and IL-21 dichotomously shape CD8+ T cell differentiation. IL-2 drives
terminal differentiation, generating cells that are poorly effective against tumors, whereas IL …