Interplay between chromatin marks in development and disease
SM Janssen, MC Lorincz - Nature Reviews Genetics, 2022 - nature.com
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
DNA methylation pathways and their crosstalk with histone methylation
J Du, LM Johnson, SE Jacobsen… - Nature reviews Molecular …, 2015 - nature.com
Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …
Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation
T Baubec, DF Colombo, C Wirbelauer, J Schmidt… - Nature, 2015 - nature.com
DNA methylation is an epigenetic modification associated with transcriptional repression of
promoters and is essential for mammalian development. Establishment of DNA methylation …
promoters and is essential for mammalian development. Establishment of DNA methylation …
DNA methyltransferases and their roles in tumorigenesis
W Zhang, J Xu - Biomarker research, 2017 - Springer
DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …
Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond
A Breiling, F Lyko - Epigenetics & chromatin, 2015 - Springer
The chemical modification of DNA bases plays a key role in epigenetic gene regulation.
While much attention has been focused on the classical epigenetic mark, 5-methylcytosine …
While much attention has been focused on the classical epigenetic mark, 5-methylcytosine …
Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
Malignancies are characterized by extensive global reprogramming of epigenetic patterns,
including gains or losses in DNA methylation and changes to histone marks. Furthermore …
including gains or losses in DNA methylation and changes to histone marks. Furthermore …
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase
DNA methylation is essential for mammalian development and physiology. Here we report
that the developmentally regulated H19 lncRNA binds to and inhibits S …
that the developmentally regulated H19 lncRNA binds to and inhibits S …
[HTML][HTML] Epigenetic silencing of tumor suppressor genes: Paradigms, puzzles, and potential
A Kazanets, T Shorstova, K Hilmi, M Marques… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …
there are a number of universal aberrations common to all cancers, one of these being the …
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …
tissues, although the mechanisms and specificity of this process are still poorly understood …