Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive
production or activation of osteoclasts leads to skeletal pathologies that affect a significant …

Colony-stimulating factor 1 receptor (CSF1R, also known as c-FMS) is a receptor tyrosine
kinase. Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R …

Osteoporosis or porous bone disorder is the result of an imbalance in an otherwise highly
balanced physiological process known as 'bone remodeling'. The immune system is …

In recent decades, the mechanism underlying bone metabolic disorders based on energy
metabolism has been heavily researched. Bone resorption by osteoclasts plays an important …

Osteoporosis is one of the major bone disorders that affects both women and men, and
causes bone deterioration and bone strength. Bone remodeling maintains bone mass and …

Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

Abstract Colony-stimulating factor-1 receptor (CSF-1R), also known as FMS kinase, is a type
I single transmembrane protein mainly expressed in myeloid cells, such as monocytes …

Renewing interest in the study of intermediate metabolism and cellular bioenergetics is
brought on by the global increase in the prevalence of metabolic illnesses. Understanding of …

Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …

Mesenchymal stem cell (MSC) exosomes promote tissue regeneration and repair, and thus
might be used to treat many diseases; however, the influence of microenvironmental …