Osteoclasts, the only cells that can resorb bone, play a central role in bone homeostasis as
well as bone damage under pathological conditions such as osteoporosis, arthritis …

Periodontitis, which is related to various systemic diseases, is a chronic inflammatory
disease caused by periodontal dysbiosis of the microbiota. Multiple factors can influence the …

Aim The underlying mechanisms connecting obesity and periodontal diseases remain
unclear. This study investigates the potential causal association of obesity with periodontal …

A well-recognized risk factor for periodontitis, diabetes mellitus (DM) aggravates periodontal
disease with increasing alveolar bone loss. As a novel myokine, irisin is closely linked with …

There is a strong association between vitamin D levels and periodontal disease based on
numerous epidemiological studies. We have previously shown that experimental deficiency …

The oral cavity presents a diverse microbiota in a dynamic balance with the host. Disruption
of the microbial community can promote dysregulation of local immune response which …

Background Osteoarthritis (OA) subsequent to acute joint injury accounts for a significant
proportion of all arthropathies. Myeloid-derived suppressor cells (MDSCs) are a …

免疫细胞与膝骨关节炎之间因果作用:一项两样本双向孟德尔随机化分析 Page 1 Chinese
Journal of Tissue Engineering Research|Vol 29|No.5|February 2025|1081 中国组织工程研究 …

The immune system is closely linked to bone homeostasis and plays a pivotal role in several
pathological and inflammatory conditions. Through various pathways it modulates various …

Introduction While periodontal disease (PD) has been associated with type 2 diabetes (T2D)
and osteoporosis, the underlying genetic mechanisms for these associations remain largely …