In the 1970s, treatment with thyroid extract was superseded by levothyroxine, a synthetic l
form of tetraiodothyronine. Since then, no major innovation has emerged for the treatment of …

Importance The benefit of thyroid hormone therapy for subclinical hypothyroidism is
uncertain. New evidence from recent large randomized clinical trials warrants an update of …

Subclinical hypothyroidism (SCH) should be considered in two categories according to the
elevation in serum thyroid-stimulating hormone (TSH) level: mildly increased TSH levels (4.0 …

Key Clinical Points Subclinical Hypothyroidism Subclinical hypothyroidism is defined as an
elevated thyrotropin level with a normal free thyroxine (T4) level. To confirm the diagnosis, a …

Objective Hypothyroidism has multiple etiologies and manifestations. Appropriate treatment
requires an accurate diagnosis and is influenced by coexisting medical conditions. This …

Background The use of levothyroxine to treat subclinical hypothyroidism is controversial. We
aimed to determine whether levothyroxine provided clinical benefits in older persons with …

Subclinical thyroid diseases—subclinical hyperthyroidism and subclinical hypothyroidism—
are common clinical entities that encompass mild degrees of thyroid dysfunction. The clinical …

Importance In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as
causal and treatable factors for cognitive decline. However, the scientific literature on these …

Thyroid hormone deficiency can have important repercussions. Treatment with thyroid
hormone in replacement doses is essential in patients with hypothyroidism. In this review …

Description: Update of the 2004 US Preventive Services Task Force (USPSTF)
recommendation on screening for thyroid disease. Methods: The USPSTF reviewed the …