Background Chromatin accessibility is crucial for gene expression regulation in specific cells
and in multiple biological processes. Assay for Transposase Accessible Chromatin with high …

Tbx20 is a member of the Tbx1 subfamily of T-box-containing genes and is known to play a
variety of fundamental roles in cardiovascular development and homeostasis as well as …

Epithelial-to-mesenchymal transitions (EMTs) of both endocardium and epicardium guide
atrioventricular heart valve formation, but the cellular complexity and small scale of this …

Defective protein quality control (PQC) systems are implicated in multiple diseases.
Molecular chaperones and co-chaperones play a central role in functioning PQC. Constant …

The inability of adult human cardiomyocytes to proliferate is an obstacle to efficient cardiac
regeneration after injury. Understanding the mechanisms that drive postnatal …

Rationale: Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart
defect which affects approximately 1 in 4,000 live births. While there are several reports of D …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Rationale: Mutations in the transcription factor TBX20 (T-box 20) are associated with
congenital heart disease. Germline ablation of Tbx20 results in abnormal heart development …

BACKGROUND: The endocardium is a crucial signaling center for cardiac valve
development and maturation. Genetic analysis has identified several human endocardial …

The endocardium is a specialized form of endothelium that lines the inner side of the heart
chambers and plays a crucial role in cardiac development. While comparatively less studied …