Cancer is a leading cause of death worldwide and around 10 million deaths in 2020 were
related to cancer. There are a number of therapeutic modalities for cancer such as …

Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …

Contemporary analyses focused on a limited number of clinical and molecular biomarkers
have been unable to accurately predict clinical outcomes in pancreatic ductal …

Background Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome
(ARDS), are devastating clinical disorders with high mortality, and for which more effective …

Cancer is not a hard-wired phenomenon but an evolutionary disease. From the onset of
carcinogenesis, cancer cells continuously adapt and evolve to satiate their ever-growing …

Background Cancer stem cells (CSC) have been implicated in tumor progression. In ovarian
carcinoma (OC), CSC drive tumor formation, dissemination and recurrence, as well as drug …

Cervical cancer is the fourth common gynecologic cancer and is considered as second
leading cause of death among women. Various strategies are applied in treatment of …

Tumors weakly infiltrated by T lymphocytes poorly respond to immunotherapy. We aimed to
unveil malignancy-associated programs regulating T cell entrance, arrest, and activation in …

Abstract Mucin 15 (MUC15) is reportedly aberrant in human malignancies, including
hepatocellular carcinoma (HCC). However, the role of MUC15 in the regulation of liver tumor …

SOX2 is a transcription factor involved in multiple stages of embryonic development. In
related reports, SOX2 was found to be abnormally expressed in tumor tissues and correlated …