Depression represents a global mental health concern, and disproportionally affects women
as they are twice more likely to be diagnosed than men. In this review, we provide a …

There are over 15 disease-modifying drugs that have been approved over the last 20 years
for the treatment of relapsing–remitting multiple sclerosis (MS), but there are limited …

Microglia, the resident immune cells of the brain, rapidly change states in response to their
environment, but we lack molecular and functional signatures of different microglial …

Microglia are brain phagocytes that participate in brain homeostasis and continuously
survey their environment for dysfunction, injury, and disease. As the first responders …

Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised
by deficits in social communication and restricted or repetitive behaviours. The clinical …

It is known that microglia morphology and function are closely related, but only few studies
have objectively described different morphological subtypes. To address this issue …

Optical clearing methods facilitate deep biological imaging by mitigating light scattering in
situ. Multi-scale high-resolution imaging requires preservation of tissue integrity for accurate …

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-
2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the …

Two-dimensional (2D) human skeletal muscle fiber cultures are ill-equipped to support the
contractile properties of maturing muscle fibers. This limits their application to the study of …

Microglia play an important role in the pathology of CNS disorders, however, there remains
significant uncertainty about the neuroprotective/degenerative role of these cells due to a …