Blood viscosity is an important determinant of local flow characteristics, which exhibits shear
thinning behavior: it decreases exponentially with increasing shear rates. Both hematocrit …

Studies performed in the last decades have highlighted the need to better understand the
contribution of the endothelium, vascular function, oxidative stress, inflammation …

The cell adhesion molecule P‐selectin plays a key role in the pathogenesis of a vaso‐
occlusive crisis (VOC) in patients with sickle cell disease (SCD). In the double‐blind …

Sickle cell anemia (SCA) is an inherited blood disorder that causes painful crises due to
vaso-occlusion of small blood vessels. The primary cause of the clinical phenotype of SCA is …

Human red blood cells (RBCs) are approximately 8 μm in diameter, but must repeatedly
deform through capillaries as small as 2 μm in order to deliver oxygen to all parts of the …

Osteonecrosis, a form of ischemic bone injury that leads to degenerative joint disease,
affects∼ 30% of people with sickle cell disease. Although osteonecrosis most commonly …

Hydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell
anemia (SCA). However, little is known about the HU NO-related effects on red blood cell …

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic
anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the …

Cell dehydration is a distinguishing characteristic of sickle cell disease and an important
contributor to disease pathophysiology. Due to the unique dependence of Hb S …

Key points Highlanders develop unique adaptative mechanisms to chronic hypoxic
exposure, including substantial haemoglobin and haematocrit increases. However, a …