Multiple gram-negative bacteria encode type III secretion systems (T3SS) that allow them to
inject effector proteins directly into host cells to facilitate colonization. To be secreted …

Oxidation of methionine disrupts the structure and function of a range of proteins, but little is
understood about the chemistry that underlies these perturbations. Using quantum …

C2 domains are widespread motifs that often serve as Ca2+-binding modules; some
proteins have more than one copy. An open issue is whether these domains, when …

We used time-resolved Förster resonance energy transfer, circular dichroism, and molecular
dynamics simulation to investigate the structural dependence of synaptotagmin 1's …

Abstract Synaptotagmin 1 (Syt1) is a synaptic vesicle protein that serves as a calcium sensor
of neuronal secretion. It is established that calcium binding to Syt1 triggers vesicle fusion …

Synaptotagmin I (Syt I) is a vesicle-localized integral membrane protein that senses the
calcium ion (Ca2+) influx to trigger fast synchronous release of neurotransmitter. How the …

The native form of globular actin, G‐actin, is formed in vivo as a result of complex post‐
translational folding processes that require ATP energy expenditure and are assisted by the …

Domains are in general less stable than the corresponding full-length proteins. Human
utrophin tandem calponin-homology (CH) domain seems to be an exception. Reversible …

Synaptotagmin I (Syt I) is the calcium ion sensor for regulated release of neurotransmitter.
How Syt I mediates this cellular event has been a question of extensive study for decades …

Abstract Fibroblast growth factor 1 (FGF1) is a heparin-binding proangiogenic protein. FGF1
lacks the conventional N-terminal signal peptide required for secretion through the …