Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors
(HDACi), a group of recently discovered 'targeted'anticancer agents. There are 18 HDACs …

The role of histone deacetylases (HDAC) and the potential of these enzymes as therapeutic
targets for cancer, neurodegenerative diseases and a number of other disorders is an area …

Histone deacetylases are key enzymes of epigenetic regulation and are therefore involved
in crucial cellular events like transcription, differentiation, apoptosis and cell division. The …

Adult stem cells are maintained in a quiescent state but are able to exit quiescence and
rapidly expand and differentiate in response to stress. The quiescent state appears to be …

The field of cancer epigenetics is evolving rapidly on several fronts. Advances in our
understanding of chromatin structure, histone modification, transcriptional activity and DNA …

Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of
human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk …

Importance of the field: Histone deacetylase (HDAC) inhibitors are being developed as a
new, targeted class of anticancer drugs. Area covered in this review: This review focuses on …

BACKGROUND Although prescription drug use is common during pregnancy, the human
teratogenic risks are undetermined for more than 90% of drug treatments approved in the …

Imatinib mesylate (IM) induces remission in chronic myelogenous leukemia (CML) patients
but does not eliminate leukemia stem cells (LSCs), which remain a potential source of …