IL-6 in inflammation, autoimmunity and cancer

T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Crosstalk of inflammatory cytokines within the breast tumor microenvironment

O Habanjar, R Bingula, C Decombat… - International journal of …, 2023 - mdpi.com
Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

The multifaced role of STAT3 in cancer and its implication for anticancer therapy

M Tolomeo, A Cascio - International journal of molecular sciences, 2021 - mdpi.com
Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …

Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors

KS Siveen, S Sikka, R Surana, X Dai, J Zhang… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

STAT3 target genes relevant to human cancers

RL Carpenter, HW Lo - Cancers, 2014 - mdpi.com
Since its discovery, the STAT3 transcription factor has been extensively studied for its
function as a transcriptional regulator and its role as a mediator of development, normal …

Role of STAT3 in cancer metastasis and translational advances

MZ Kamran, P Patil, RP Gude - BioMed research international, 2013 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic
transcription factor, originally discovered as a transducer of signal from cell surface …

The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy

M Garg, MK Shanmugam, V Bhardwaj… - Medicinal research …, 2021 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

STATs in oncogenesis

T Bowman, R Garcia, J Turkson, R Jove - Oncogene, 2000 - nature.com
Since their discovery as key mediators of cytokine signaling, considerable progress has
been made in defining the structure-function relationships of Signal Transducers and …

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

T Hirano, K Ishihara, M Hibi - Oncogene, 2000 - nature.com
Members of the IL-6 cytokine family are involved in a variety of biological responses,
including the immune response, inflammation, hematopoiesis, and oncogenesis by …

Signal transducer and activator of transcription‐3, inflammation, and cancer: how intimate is the relationship?

BB Aggarwal, AB Kunnumakkara… - Annals of the New …, 2009 - Wiley Online Library
Signal transducer and activator of transcription‐3 (STAT‐3) is one of six members of a family
of transcription factors. It was discovered almost 15 years ago as an acute‐phase response …