Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The
underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still …

Pain has a strong emotional component and is defined by its unpleasantness. Chronic pain
represents a complex disorder with anxio-depressive symptoms and cognitive deficits …

Abstract Background Silica nanoparticles (SiO 2-NPs) are naturally enriched and broadly
utilized in the manufacturing industry. While previous studies have demonstrated toxicity in …

Parkinson's disease (PD) is characterized by motor and non-motor symptoms associated
with dopaminergic and non-dopaminergic injury. Vortioxetine is a multimodal serotonergic …

Background Chronic alcohol exposure induces cognitive impairment and NLRP3
inflammasome activation in the mPFC (medial prefrontal cortex). Mitophagy plays a crucial …

Microcystins (MCs), a group of most widespread freshwater cyanotoxins that possess strong
neurotoxicity, can adversely affect brain structures and functions and are linked to …

Brominated flame retardants (BFRs) reduce flammability in a wide range of products
including electronics, carpets, and paint, but leach into the environment to result in …

Objectives: Alcohol abuse is known to result in behavioral impairments (such as increased
impulsivity, aggressive, and suicidal behavior), but the neurobiological basis for these …

Chronic alcohol drinking can damage the central nervous system via many mechanisms.
One of these may involve a deficiency of an essential nutrient, thiamine, as a result of …

Persistent regional glucocorticoid (GC) dysregulation in alcohol-withdrawn subjects
emerges as a key factor responsible for protracted molecular and neural alterations …