Understanding brain states across spacetime informed by whole-brain modelling

J Vohryzek, J Cabral, P Vuust… - … of the Royal …, 2022 - royalsocietypublishing.org
In order to survive in a complex environment, the human brain relies on the ability to flexibly
adapt ongoing behaviour according to intrinsic and extrinsic signals. This capability has …

Toward naturalistic neuroscience: Mechanisms underlying the flattening of brain hierarchy in movie-watching compared to rest and task

ML Kringelbach, YS Perl, E Tagliazucchi, G Deco - Science Advances, 2023 - science.org
Identifying the functional specialization of the brain has moved from using cognitive tasks
and resting state to using ecological relevant, naturalistic movies. We leveraged a large …

The INSIDEOUT framework provides precise signatures of the balance of intrinsic and extrinsic dynamics in brain states

G Deco, Y Sanz Perl, H Bocaccio… - Communications …, 2022 - nature.com
Finding precise signatures of different brain states is a central, unsolved question in
neuroscience. We reformulated the problem to quantify the 'inside out'balance of intrinsic …

Temporal irreversibility of large-scale brain dynamics in Alzheimer's disease

J Cruzat, R Herzog, P Prado, Y Sanz-Perl… - Journal of …, 2023 - Soc Neuroscience
Healthy brain dynamics can be understood as the emergence of a complex system far from
thermodynamic equilibrium. Brain dynamics are temporally irreversible and thus establish a …

Different hierarchical reconfigurations in the brain by psilocybin and escitalopram for depression

G Deco, Y Sanz Perl, S Johnson, N Bourke… - Nature Mental …, 2024 - nature.com
Effective interventions for neuropsychiatric disorders may work by rebalancing the brain's
functional hierarchical organization. Here we directly investigated the effects of two different …

Decomposing the local arrow of time in interacting systems

CW Lynn, CM Holmes, W Bialek, DJ Schwab - Physical review letters, 2022 - APS
We show that the evidence for a local arrow of time, which is equivalent to the entropy
production in thermodynamic systems, can be decomposed. In a system with many degrees …

Is stochastic thermodynamics the key to understanding the energy costs of computation?

DH Wolpert, J Korbel, CW Lynn, F Tasnim… - Proceedings of the …, 2024 - pnas.org
The relationship between the thermodynamic and computational properties of physical
systems has been a major theoretical interest since at least the 19th century. It has also …

Theoretical foundations of studying criticality in the brain

Y Tian, Z Tan, H Hou, G Li, A Cheng, Y Qiu… - Network …, 2022 - direct.mit.edu
Criticality is hypothesized as a physical mechanism underlying efficient transitions between
cortical states and remarkable information-processing capacities in the brain. While …

High-order brain interactions in ketamine during rest and task: a double-blinded cross-over design using portable EEG on male participants

R Herzog, FM Barbey, MN Islam… - Translational …, 2024 - nature.com
Ketamine is a dissociative anesthetic that induces a shift in global consciousness states and
related brain dynamics. Portable low-density EEG systems could be used to monitor these …

Rare long-range cortical connections enhance human information processing

G Deco, YS Perl, P Vuust, E Tagliazucchi, H Kennedy… - Current Biology, 2021 - cell.com
What are the key topological features of connectivity critically relevant for generating the
dynamics underlying efficient cortical function? A candidate feature that has recently …