Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

The intestinal mucosa provides a selective permeable barrier for nutrient absorption and
protection from external factors. It consists of epithelial cells, immune cells and their …

The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of
contents from the intestinal lumen into the intestinal tissue and systemic circulation. A …

Backgrounds & Aims Increased permeability is implicated in the pathogenesis of intestinal
disease. In vitro and in vivo studies have linked down-regulation of the scaffolding protein …

Key studies published in 2020 demonstrate that an impaired intestinal barrier precedes
clinical diagnosis of inflammatory bowel disease (IBD) by years. Furthermore, studies …

The gut microbiota is indispensable for maintaining host health by enhancing the host's
digestive capacity, safeguarding the intestinal epithelial barrier, and preventing pathogen …

Background & aims Inflammatory bowel diseases (IBD) are affected by dietary factors,
including nondigestible carbohydrates (fibers), which are fermented by colonic microbes …

The epidemiology of inflammatory bowel disease (IBD) has undergone considerable shifts
since its emergence in the Western world over a century ago, especially in the last few …

Background & Aims Case-control studies have shown that patients with Crohn's disease
(CD) have a microbial composition different from healthy individuals. Although the causes of …

A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …