Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …

Inflammation In the absence of pathogens occurs in all tissues in response to a wide range
of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process …

The two major subtypes of diffuse large B cell lymphoma (DLBCL)—activated B cell–like
(ABC) and germinal center B cell–like (GCB)—arise by distinct mechanisms, with ABC …

Background Waldenström's macroglobulinemia is an incurable, IgM-secreting
lymphoplasmacytic lymphoma (LPL). The underlying mutation in this disorder has not been …

Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE)
is implicated in geographic atrophy (GA), an advanced form of age-related macular …

Abstract Myeloid differentiation factor 88 (MYD88) L265P somatic mutation is highly
prevalent in Waldenström macroglobulinemia (WM) and supports malignant growth through …

The continuous emergence of infectious pathogens along with antimicrobial resistance
creates a need for an alternative approach to treat infectious diseases. Targeting host factor …

Summary Complement receptor 3 (CR3) activation in microglia is involved in
neuroinflammation-related brain disorders and pruning of neuronal synapses. Hypoxia …

Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed
cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and …

There is increasing evidence that innate and adaptive immune responses are intimately
linked. This linkage is in part mediated through the recognition of conserved microbial …