Pichia pastoris has been recognized as one of the most industrially important hosts for
heterologous protein production. Despite its high protein productivity, the optimization of P …

The ability to measure all process variables is of great importance in the field of bioprocess
monitoring and control, and continuous, real‐time measurements are highly desired. The …

Over the last 10 years use of isothermal microcalorimetry in the biological and biomedical
field has been a increasing. Several biomedical applications such as detection and …

Understanding the growth characteristics of microorganisms is an essential step in
bioprocessing, not only because product formation may be growth-associated but also …

The process analytical technology (PAT) initiative is now 10 years old. This has resulted in
the development of many tools and software packages dedicated to PAT application on …

At specific growth rates above a particular critical value, Crabtree-positive microorganisms
exceed their respiratory capacity and enter diauxic growth metabolism. Excess substrate is …

The state-of-routine monitoring items established in the bioprocess industry as well as some
important state-of-the-art methods are briefly described and the potential pitfalls discussed …

Lack of appropriate process models, reliable online sensors, and process variability in
bioprocess systems are poising challenges in real-time monitoring and control of critical …

Nowadays, filamentous fungi play remarkable roles in our lives, from producing wide-
ranging compounds (eg, citric acid, antibiotics, anti-cancer drugs, enzymes, etc.) to …

Soft sensors are the combination of robust on-line sensor signals with mathematical models
for deriving additional process information. Here, we apply this principle to a microbial …