Kidney diseases are serious health problems affecting> 800 million individuals worldwide.
The high number of affected individuals and the severe consequences of kidney dysfunction …

Diabetic kidney disease (DKD) is a major diabetic complication and global health concern,
occurring in nearly 30% to 40% of people with diabetes. Importantly, several therapeutic …

Toll-like receptor-4 (TLR4) and sodium-glucose co-transporter 2 (SGLT2) signaling is
involved in the pathogenesis of diabetes-associated kidney diseases. The purpose of this …

Mitophagy maintains cellular homeostasis by eliminating damaged mitochondria.
Accumulated damaged mitochondria can lead to oxidative stress and cell death. Induction of …

Background Hyperglycaemia influences the development of glomerular endothelial cell
damage and nowhere is this more evident than in the progression of diabetic kidney disease …

The endoplasmic reticulum (ER) is indispensable for maintaining normal life activities.
Dysregulation of the ER function results in the accumulation of harmful proteins and lipids …

Ferroptosis of the retinal pigment epithelial (RPE) cells leads to retinal neuron injury and
even visual loss. Our study aims to investigate the role of the SET domain with lysine …

The occurence and development of tumors is a complicated process, which not only
depends on the mutation or deletion of genes, but also is affected by epigenetic regulation …

肿瘤的发生是个复杂的过程， 不仅取决于本身基因的突变或缺失， 还受表观遗传调控的影响。
近年来研究表明甲基化修饰在转录调控、 异染色质的形成、 X 染色体失活、 DNA 损伤 …