Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Cytochrome P450 oxidoreductase (POR) is an enzyme that is essential for multiple
metabolic processes, chiefly among them are reactions catalyzed by cytochrome P450 …

A newborn infant with ambiguous genitalia is a complex enough problem to unravel without
any further clouding by confusing terms. The nomenclature 'intersex','hermaphrodite'and …

Congenital adrenal hyperplasia (CAH) is one of the most common inherited metabolic
disorders. It comprises a group of autosomal recessive disorders caused by the deficiency of …

The enzymes and pathways of steroidogenesis are familiar to most endocrinologists, but the
biochemistry and molecular biology of these processes are still being studied. This chapter …

P450 oxidoreductase (POR) is an electron-donating flavoprotein required for the activity of
all microsomal cytochrome P450 enzymes. We sequenced 5,655 bp of the POR gene in a …

Aim: Recently a SNP of the gene encoding P450 oxidoreductase (POR* 28; rs1057868C> T)
has been associated with increased in vivo CYP3A activity using midazolam as a drug …

Disorders of sex development (DSDs) are a diverse group of conditions that can be
challenging to diagnose accurately using standard phenotypic and biochemical …

Background CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about
50% of drugs on the market, with a large overlap in their specificities. We investigated the …

Abstract Context: Cytochrome P450 oxidoreductase (POR) deficiency is a rare autosomal
recessive disorder characterized by skeletal dysplasia, adrenal dysfunction, disorders of sex …