Toward personalized synchrotron microbeam radiation therapy

E Engels, N Li, J Davis, J Paino, M Cameron… - Scientific reports, 2020 - nature.com
Synchrotron facilities produce ultra-high dose rate X-rays that can be used for selective
cancer treatment when combined with micron-sized beams. Synchrotron microbeam …

Validation of a Monte Carlo simulation for microbeam radiation therapy on the imaging and medical beamline at the Australian Synchrotron

A Dipuglia, M Cameron, JA Davis, IM Cornelius… - Scientific Reports, 2019 - nature.com
Abstract Microbeam Radiation Therapy (MRT) is an emerging cancer treatment modality
characterised by the use of high-intensity synchrotron-generated x-rays, spatially …

A novel approach to double-strand DNA break analysis through γ-H2AX confocal image quantification and bio-dosimetry

M Valceski, E Engels, S Vogel, J Paino, D Potter… - Scientific Reports, 2024 - nature.com
DNA damage occurs in all living cells. γ-H2AX imaging by fluorescent microscopy is widely
used across disciplines in the analysis of double-strand break (DSB) DNA damage. Here we …

First experimental measurement of the effect of cardio‐synchronous brain motion on the dose distribution during microbeam radiation therapy

M Duncan, M Donzelli, P Pellicioli… - Medical …, 2020 - Wiley Online Library
Purpose Microbeam radiation therapy (MRT) is an emerging radiation oncology modality
ideal for treating inoperable brain tumors. MRT employs quasi‐parallel beams of low …

Design, construction, and dosimetry of 3D printed heterogeneous phantoms for synchrotron brain cancer radiation therapy quality assurance

JPO Bustillo, J Paino, M Barnes, J Cayley… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. This study aims to design, manufacture, and test 3D printed quality assurance
(QA) dosimetry phantoms for synchrotron brain cancer radiation therapy at the Australian …

Film dosimetry studies for patient specific quality assurance in microbeam radiation therapy

A Ocadiz, J Livingstone, M Donzelli, S Bartzsch… - Physica Medica, 2019 - Elsevier
Microbeam radiation therapy (MRT) uses synchrotron arrays of X-ray microbeams to take
advantage of the spatial fractionation effect for normal tissue sparing. In this study …

Performance characterization of a novel hybrid dosimetry insert for simultaneous spatial, temporal, and motion‐included dosimetry for MR‐linac

P Uijtewaal, P Borman, B Cote, Y LeChasseur… - Medical …, 2024 - Wiley Online Library
Background Several (online) adaptive radiotherapy procedures are available to maximize
healthy tissue sparing in the presence of inter/intrafractional motion during stereotactic body …

A comparative dosimetry study of an alanine dosimeter with a PTW PinPoint chamber at ultra-high dose rates of synchrotron radiation

YS Soliman, P Pellicioli, WB Beshir, AA Abdel-Fattah… - Physica Medica, 2020 - Elsevier
The use of synchrotron X-ray sources provides innovative approaches in radiation therapy.
The unique possibility to generate quasi-parallel beams promoted the development of …

Characterisation and evaluation of a PNP strip detector for synchrotron microbeam radiation therapy

JA Davis, JR Paino, A Dipuglia… - Biomedical Physics …, 2018 - iopscience.iop.org
Abstract The Quality Assurance requirements of detectors for Synchrotron Micro-beam
Radiation Therapy are such that there are limited commercial systems available. The high …

Synchrotron X-ray microbeam dosimetry with a 20 micrometre resolution scintillator fibre-optic dosimeter

J Archer, E Li, M Petasecca, A Stevenson… - Journal of …, 2018 - journals.iucr.org
Cancer is one of the leading causes of death worldwide. External beam radiation therapy is
one of the most important modalities for the treatment of cancers. Synchrotron microbeam …