Intracellular accumulation of abnormal proteins with conformational changes is the defining
neuropathological feature of neurodegenerative diseases. The pathogenic proteins that …

Neurodegenerative diseases are a pathologically, clinically and genetically diverse group of
disorders without effective disease-modifying therapies. Pathologically, these disorders are …

The development of technologies for the in vitro amplification of abnormal conformations of
prion protein (PrPSc) has generated the potential for sensitive detection of prions. Here we …

Prions are the unconventional infectious agents responsible for transmissible spongiform
encephalopathies, which appear to be composed mainly or exclusively of the misfolded …

Alzheimer disease (AD) and chronic traumatic encephalopathy (CTE) involve the abnormal
accumulation in the brain of filaments composed of both three-repeat (3R) and four-repeat …

The diagnosis and treatment of diseases involving tau-based pathology such as Alzheimer
disease and certain frontotemporal dementias is hampered by the inability to detect …

We recently developed a new in vitro amplification technology, designated “real-time
quaking-induced conversion (RT-QUIC)”, for detection of the abnormal form of prion protein …

Prions are unconventional infectious agents composed exclusively of misfolded prion
protein (PrP Sc), which transmits the disease by propagating its abnormal conformation to …

Prions are the infectious agents responsible for prion diseases, which appear to be
composed exclusively by the misfolded prion protein (PrPSc). Disease is transmitted by the …

Exosomes are small membrane‐bound vesicles released from cells and found in vivo in
most biological fluids. Functions reported for exosomes include cell–cell communication …