Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

For more than a decade, it has been known that mammalian cells use shelterin to protect
chromosome ends. Much progress has been made on the mechanism by which shelterin …

Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes.
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …

Mammalian telomeres consist of (TTAGGG) n repeats. Transcription of the C-rich strand
generates a G-rich RNA, termed TERRA, containing G-quadruplex structures. Recent …

Telomere length maintenance is a requisite feature of cellular immortalization and a
hallmark of human cancer. While most human cancers express telomerase activity,∼ 10 …

Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's
lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short …

Senescence was classically defined as an irreversible cell cycle arrest in G1 phase (G1 exit)
triggered by eroded telomeres in aged primary cells. The molecular basis of this G1 arrest is …

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere
maintenance mechanism that occurs in a subset of cancers. One of the hallmarks of ALT …

Natural chromosome ends resemble double-stranded DNA breaks, but they do not activate
a damage response in healthy cells. Telomeres therefore have evolved to solve the'end …

The program of cellular senescence is involved in both the G1 and G2 phase of the cell
cycle, limiting G1/S and G2/M progression respectively, and resulting in prolonged cell cycle …