Reactive oxygen species (ROS), a class of highly bioactive molecules, have been widely
studied in various types of cancers. ROS are considered to be normal byproducts of …

Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …

Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

The epithelial lining of the airway forms the first barrier against environmental insults, such
as inhaled cigarette smoke, which is the primary risk factor for the development of chronic …

Oxidative stress is now recognized as a major predisposing factor in the pathogenesis of
COPD. Existing therapies for COPD are ineffective at halting disease progression, with …

Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …

Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely
implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays …

Background Cigarette smoking is the major risk factor for COPD, leading to chronic airway
inflammation. We hypothesized that cigarette smoke induces structural and functional …

Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen
species (ROS) production has been implicated in COPD pathogenesis by accelerating …