Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …

Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …

Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

The expansion of adipose tissue (AT) in obesity is accompanied by the accumulation of
immune cells that contribute to a state of low‐grade, chronic inflammation and dysregulated …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

Age-related macular degeneration is a prevalent neuroinflammatory condition and a major
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …

Obesity is characterized by an accumulation of macrophages in adipose, some of which
form distinct crown-like structures (CLS) around fat cells. While multiple discrete adipose …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

Obesity and type 2 diabetes mellitus (T2D) are global pandemics. Worldwide, the
prevalence of obesity has nearly tripled since 1975 and the prevalence of T2D has almost …