Innate sensing of malaria parasites

RT Gazzinelli, P Kalantari, KA Fitzgerald… - Nature Reviews …, 2014 - nature.com
Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …

Malarial hemozoin: from target to tool

LM Coronado, CT Nadovich, C Spadafora - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background Malaria is an extremely devastating disease that continues to affect millions of
people each year. A distinctive attribute of malaria infected red blood cells is the presence of …

Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo

J Hu, J Liu, F Xue, G Halverson, M Reid… - Blood, The Journal …, 2013 - ashpublications.org
Terminal erythroid differentiation starts from morphologically recognizable proerythroblasts
that proliferate and differentiate to generate red cells. Although this process has been …

[HTML][HTML] Severe malarial anemia: innate immunity and pathogenesis

DJ Perkins, T Were, GC Davenport… - … journal of biological …, 2011 - ncbi.nlm.nih.gov
Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections
with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in …

Monocytes and macrophages in malaria: protection or pathology?

CLL Chua, G Brown, JA Hamilton, S Rogerson… - Trends in …, 2013 - cell.com
Recruitment and activation of monocytes and macrophages are essential for clearance of
malaria infection, but these have also been associated with adverse clinical outcomes. In …

[HTML][HTML] Maternal anemia at first antenatal visit: prevalence and risk factors in a malaria-endemic area in Benin

S Ouédraogo, GK Koura… - The American journal …, 2012 - ncbi.nlm.nih.gov
The risk factors for maternal anemia (hemoglobin level less than 110 g/L) were studied in
human immunodeficiency virus–negative pregnant women in Benin at the time of first …

Entire expressed peripheral blood transcriptome in pediatric severe malarial anemia

SB Anyona, Q Cheng, SA Wasena, SW Osata… - Nature …, 2024 - nature.com
This study on severe malarial anemia (SMA: Hb< 6.0 g/dL), a leading global cause of
childhood morbidity and mortality, compares the entire expressed whole blood host …

Severe malaria: Biology, clinical manifestation, pathogenesis and consequences

SN Balaji, R Deshmukh, V Trivedi - Journal of Vector Borne …, 2020 - journals.lww.com
Every year, millions of people are infected with malaria, resulting in significant economic
losses to the developing and developed nations. The malaria parasite pursues a …

Molecular mechanisms of hematological and biochemical alterations in malaria: a review

IU Okagu, RN Aguchem, CA Ezema… - Molecular and …, 2022 - Elsevier
Malaria is a dangerous disease that contributes to millions of hospital visits and hundreds of
thousands of deaths, especially in children residing in sub-Saharan Africa. Although several …

Erythropoiesis in malaria infections and factors modifying the erythropoietic response

VA Pathak, K Ghosh - Anemia, 2016 - Wiley Online Library
Anemia is the primary clinical manifestation of malarial infections and is responsible for the
substantial rate of morbidity. The pathophysiology discussed till now catalogued several …