Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling
DNA methylation microarrays can be employed to interrogate cell-type composition in
complex tissues. Here, we expand reference-based deconvolution of blood DNA …
complex tissues. Here, we expand reference-based deconvolution of blood DNA …
Linking prenatal environmental exposures to lifetime health with epigenome-wide association studies: state-of-the-science review and future recommendations
Background: The prenatal environment influences lifetime health; epigenetic mechanisms
likely predominate. In 2016, the first international consortium paper on cigarette smoking …
likely predominate. In 2016, the first international consortium paper on cigarette smoking …
Mechanisms of DNA methylation in virus-host interaction in hepatitis b infection: Pathogenesis and oncogenetic properties
Hepatitis B virus (HBV), the well-studied oncovirus that contributes to the majority of
hepatocellular carcinomas (HCC) worldwide, can cause a severe inflammatory …
hepatocellular carcinomas (HCC) worldwide, can cause a severe inflammatory …
Cell-specific characterization of the placental methylome
Background DNA methylation (DNAm) profiling has emerged as a powerful tool for
characterizing the placental methylome. However, previous studies have focused primarily …
characterizing the placental methylome. However, previous studies have focused primarily …
Epigenetics and ADHD: reflections on current knowledge, research priorities and translational potential
Attention-deficit/hyperactivity disorder (ADHD) is a common and debilitating
neurodevelopmental disorder influenced by both genetic and environmental factors …
neurodevelopmental disorder influenced by both genetic and environmental factors …
Gestational perfluoroalkyl substance exposure and DNA methylation at birth and 12 years of age: a longitudinal epigenome-wide association study
Y Liu, MN Eliot, GD Papandonatos… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: DNA methylation alterations may underlie associations between gestational
perfluoroalkyl substances (PFAS) exposure and later-life health outcomes. To the best of our …
perfluoroalkyl substances (PFAS) exposure and later-life health outcomes. To the best of our …
Prenatal exposure to per-and polyfluoroalkyl substances, umbilical cord blood DNA methylation, and cardio-metabolic indicators in newborns: the healthy start study
Background: Per-and polyfluoroalkyl substances (PFAS) are environmentally persistent
chemicals widely detected in women of reproductive age. Prenatal PFAS exposure is …
chemicals widely detected in women of reproductive age. Prenatal PFAS exposure is …
Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation
A Kotsakis Ruehlmann, S Sammallahti… - Molecular …, 2023 - nature.com
Prenatal maternal stressful life events are associated with adverse neurodevelopmental
outcomes in offspring. Biological mechanisms underlying these associations are largely …
outcomes in offspring. Biological mechanisms underlying these associations are largely …
A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes
Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …
diseases and environmental risk factors and may be causally implicated in disease …
Cell-type heterogeneity: Why we should adjust for it in epigenome and biomarker studies
L Qi, AE Teschendorff - Clinical Epigenetics, 2022 - Springer
Most studies aiming to identify epigenetic biomarkers do so from complex tissues that are
composed of many different cell-types. By definition, these cell-types vary substantially in …
composed of many different cell-types. By definition, these cell-types vary substantially in …