The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …

During the millions of years they have coexisted with their hosts, viruses have learned how
to manipulate host immune control mechanisms. Viral gene functions provide an overview of …

Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a
healthy immunocompetent host throughout life without being eliminated by the immune …

Human cytomegalovirus (HCMV) is a herpes virus that infects and is carried by 70–100% of
the world's population. During its evolution, this virus has developed mechanisms that allow …

The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Human cytomegalovirus (HCMV) in clinical material cannot replicate efficiently in vitro until it
has adapted by mutation. Consequently, wild-type HCMV differ fundamentally from the …

In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …

Natural killer (NK) cells are crucial in the control of cytomegalovirus infections in mice and
humans. Here we show that the viral UL141 gene product has an immunomodulatory …

Human cytomegalovirus (HCMV) causes lifelong, persistent infections and its survival is
under intense, continuous selective pressure from the immune system. A key aspect of …

Human cytomegalovirus (HCMV) employs a variety of strategies to modify or evade the host
immune response, and natural killer (NK) cells play a crucial role in controlling …