Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

Forward genetic screens are powerful tools for the discovery and functional annotation of
genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short …

Zebrafish have become a popular organism for the study of vertebrate gene function,. The
virtually transparent embryos of this species, and the ability to accelerate genetic studies by …

The widespread availability of programmable site-specific nucleases now enables targeted
gene disruption in the zebrafish. In this study, we applied site-specific nucleases to generate …

The use of CRISPR/Cas9 as a genome-editing tool in various model organisms has
radically changed targeted mutagenesis. Here, we present a high-throughput targeted …

The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro
experiments and developmental toxicity studies. Zebrafish may be used to determine the …

We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …

In Darwin's and Mendel's times, researchers investigated a wealth of organisms, chosen to
solve particular problems for which they seemed especially well suited. Later, a focus on a …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Monitoring and assessing the effects of contaminants in the aquatic eco‐environment is
critical in protecting human health and the environment. The zebrafish has been widely used …