Epigenetic inheritance is a phenomenon whereby stochastic or signal-induced changes to
parental germline epigenome modulate phenotypic output in one or more subsequent …

The agouti viable yellow (A vy) allele is an insertional mutation in the mouse genome
caused by a variably methylated intracisternal A particle (VM-IAP) retrotransposon. A vy …

The mechanism behind transgenerational epigenetic inheritance is unclear, particularly
through the maternal grandparental line. We previously showed that disruption of folate …

Key points Folate (folic acid) deficiency and mutations in folate‐related genes in humans
result in megaloblastic anaemia. Folate metabolism, which requires the enzyme methionine …

Prenatal alcohol exposure disturbs fetal and placental growth and can alter DNA
methylation (DNAm). Supplementation with the methyl donor choline can increase fetal and …

One-carbon metabolism, including the folate cycle, has a crucial role in fetal development
though its molecular function is complex and unclear. The hypomorphic Mtrr gt allele is …

Abnormal uptake or metabolism of folate increases risk of human pregnancy complications,
though the mechanism is unclear. Here, we explore how defective folate metabolism …

Lung cancer is the leading cause of cancer-related death. Intriguingly, males with non-small
cell lung cancer (NSCLC) have a higher mortality rate than females. Here, we investigated …

Résumé L'environnement et les habitudes de vie du père peuvent avoir une incidence sur la
qualité de ses spermatozoïdes. De récents rapports ont démontré que la santé des …

The mechanism behind transgenerational epigenetic inheritance (TEI) is unclear,
particularly through the maternal line. We previously showed that disruption of folate …