Fusions of Cas9 domains and nucleic acid-editing domains
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for the targeted editing of nucleic acids, including editing a single site within the …
are useful for the targeted editing of nucleic acids, including editing a single site within the …
Adenosine nucleobase editors and uses thereof
DR Liu, N Gaudelli - US Patent 10,113,163, 2018 - Google Patents
The disclosure provides adenosine deaminases that are capable of deaminating adenosine
in DNA. The disclosure also provides fusion proteins comprising a Cas9 (eg, a Cas9 …
in DNA. The disclosure also provides fusion proteins comprising a Cas9 (eg, a Cas9 …
Methods for nucleic acid editing
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for the targeted editing of nucleic acids, including editing a single site within the …
are useful for the targeted editing of nucleic acids, including editing a single site within the …
Delivery system for functional nucleases
Abstract Compositions, methods, strategies, kits, and systems for the supercharged protein-
mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are …
mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are …
Nucleobase editors comprising nucleic acid programmable DNA binding proteins
2019-03-13 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
CAS9 variants and uses thereof
DR Liu, JP Guilinger, DB Thompson - US Patent 10,858,639, 2020 - Google Patents
Some aspects of this disclosure provide compositions, methods, and kits for improving the
specificity of RNA-programmable endonucleases, such as Cas9. Also provided are variants …
specificity of RNA-programmable endonucleases, such as Cas9. Also provided are variants …
Cas variants for gene editing
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for the targeted editing of nucleic acids, including editing a single site within the …
are useful for the targeted editing of nucleic acids, including editing a single site within the …
AAV delivery of nucleobase editors
DR Liu, JM Levy, WH Yeh - US Patent 11,306,324, 2022 - Google Patents
2018-02-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Cas variants for gene editing
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for the targeted editing of nucleic acids, including editing a single site within the …
are useful for the targeted editing of nucleic acids, including editing a single site within the …