Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

The first life forms evolved in a highly reducing environment. This reduced state is still
carried by cells today, which makes the concept of “reductive stress” somewhat redundant …

Iron is essential for several vital biological processes. Its deficiency or overload drives to the
development of several pathologies. To maintain iron homeostasis, the organism controls …

Publisher Summary This chapter discusses the role of free radicals and catalytic metal ions
in human disease. The importance of transition metal ions in mediating oxidant damage …

BACKGROUND: Besides transferrin iron, which represents the normal form of circulating
iron, non-transferrin bound iron (NTBI) has been identified in the plasma of patients with …

Reactive oxygen species are constantly formed in the human body and removed by
antioxidant defenses. An antioxidant is a substance that, when present at low concentrations …

The role played by free radicals in normal physiology and in human diseases is reviewed.
Oxidative stress occurs in most, if not all, human diseases. Understanding of the role played …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

The antioxidants in the aqueous phase of human plasma include ceruloplasmin, albumin
(the protein itself and possibly also albumin-bound bilirubin), ascorbic acid, transferrin …

Considering that the development of hepatic lesions related to iron overload diseases might
be a result of abnormally expressed hepatic genes, we searched for new genes up …