Tinnitus involves the percept of a sound or sounds in the ear or head without an external
source. Most individuals experiencing tinnitus have a neutral reaction to the percept …

Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …

The noise-induced and age-related loss of synaptic connections between auditory-nerve
fibers and cochlear hair cells is well-established from histopathology in several mammalian …

Presbycusis, or age‐related hearing loss (ARHL), occurs in most mammals with variations in
the age of onset, rate of decline, and magnitude of degeneration in the central nervous …

Prior work has provided extensive documentation of threshold sensitivity and sensory hair
cell losses after noise exposure. It is now clear, however, that cochlear synaptic loss …

Resident cochlear macrophages rapidly migrate into the inner hair cell synaptic region and
directly contact the damaged synaptic connections after noise-induced synaptopathy …

Aging listeners, even in the absence of overt hearing loss measured as changes in hearing
thresholds, often experience impairments processing temporally complex sounds such as …

Abstract Models of the human auditory periphery range from very basic functional
descriptions of auditory filtering to detailed computational models of cochlear mechanics …

The purpose of this study was to test the hypothesis that listeners with frequent exposure to
loud music exhibit deficits in suprathreshold auditory performance consistent with cochlear …

Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between
inner hair cells (IHCs) and auditory-nerve fibers (ANFs), first reported in CBA/CaJ mice …