Cisplatin for cancer therapy and overcoming chemoresistance

R Ranasinghe, ML Mathai, A Zulli - Heliyon, 2022 - cell.com
Cisplatin spearheads the anticancer chemotherapeutics in present-day use although acute
toxicity is its primary impediment factor. Among a plethora of experimental medications, a …

[HTML][HTML] Anticancer effects of natural phytochemicals in anaplastic thyroid cancer

Y Li, J Zhang, H Zhou, Z Du - Oncology Reports, 2022 - spandidos-publications.com
Anaplastic thyroid cancer (ATC) is an aggressive and lethal malignancy having a dismal
prognosis. Phytochemicals are bioactive components obtained from plants that have been …

Functionalized mesoporous silica nanoparticles for drug-delivery to multidrug-resistant cancer cells

N Igaz, P Bélteky, D Kovács, C Papp… - International Journal …, 2022 - Taylor & Francis
Background Multidrug resistance is a common reason behind the failure of chemotherapy.
Even if the therapy is effective, serious adverse effects might develop due to the low …

Deep learning can predict bevacizumab therapeutic effect and microsatellite instability directly from histology in epithelial ovarian cancer

CW Wang, YC Lee, YJ Lin, NP Firdi, H Muzakky… - Laboratory …, 2023 - Elsevier
Epithelial ovarian cancer (EOC) remains a significant cause of mortality among gynecologic
cancers, with the majority of cases being diagnosed at an advanced stage. Before targeted …

Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin

Z Guo, J Huang, X Huo, C Huang, X Yu, Y Sun… - Science China Life …, 2024 - Springer
Ovarian cancer is the most lethal and aggressive gynecological cancer with a high
recurrence rate and is often diagnosed late. In ovarian cancer, multiple metabolic enzymes …

Research progress on the application of organoids in gynecological tumors

Y Shen, Y Wang, S Wang, C Li, FJ Han - Frontiers in Pharmacology, 2024 - frontiersin.org
Organoids are in vitro 3D models that maintain their own tissue structure and function. They
largely overcome the limitations of traditional tumor models and have become a powerful …

Exploiting the Warburg Effect: Co‐Delivery of Metformin and FOXK2 siRNA for Ovarian Cancer Therapy

W Zhou, X Ma, J Xiao, X He, C Liu, X Xu… - Small …, 2024 - Wiley Online Library
Ovarian cancer remains a significant health issue worldwide, often facing limitations in
treatment due to side effects and drug resistance. Tumor cells typically undergo the …

miR-4461 regulates the proliferation and metastasis of ovarian cancer cells and cisplatin resistance

L Dou, Y Zhang - Frontiers in oncology, 2021 - frontiersin.org
microRNAs (miRNAs) are of great significance in cancer treatment, which may have a
desirable result on the regulation of tumorigenesis, progression, recurrence, and chemo …

Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma

M Yin, C Lu, H Zhou, Q Liu, J Yang - BMC Women's Health, 2023 - Springer
Objective Ovarian clear cell carcinoma (OCCC) is a distinct entity from epithelial ovarian
cancer. The prognosis of advanced and recurrent disease is very poor due to resistance to …

Targeting ATP synthase by bedaquiline as a therapeutic strategy to sensitize ovarian cancer to cisplatin

H Zhu, Q Chen, L Zhao, P Hu - Nutrition and Cancer, 2023 - Taylor & Francis
Cisplatin is a common chemotherapeutic drug for treating ovarian cancer, but its clinical
efficacy is hampered by intrinsic and acquired resistance. Previous studies had shown …