Solid phase screenings of one bead one compound (OBOC) libraries have been widely
used to find ligands with pharmacological and analytical uses, and to purify or detect …

The interest in therapeutic monoclonal antibodies (mAbs) has significantly grown in the
pharmaceutical industry, exceeding 100 FDA mAbs approved. Although the upstream …

Immunoglobulin E (IgE) is pivotal for manifestation and persistence of most immediate-type
allergies and some asthma phenotypes. Consequently, IgE represents a crucial target for …

We describe a method to develop affinity chromatography matrices with short peptide
ligands for protein purification. The method entitles the following:(a) synthesis of a …

Small peptides containing fewer than 10 amino acids are promising ligand candidates with
which to build affinity chromatographic systems for industrial protein purification. The …

Screening of one-bead-one-compound (OBOC) libraries is a proven procedure for the
identification of protein-binding ligands. The demand for binders with high affinity and …

Since introduction of sinapinic acid (SA) and α‐cyano‐4‐hydroxycinnamic acid as matrices,
successful application of matrix‐assisted laser desorption/ionization mass spectrometry …

One bead–one peptide libraries allow the screening of suitable ligands for any target
protein. Short cyclic peptides are ideal ligands for affinity chromatography because of their …

ABSTRACT Liraglutide, developed by Novo Nordisk, is applied in Type 2 diabetes and
obesity treatment. Several solid‐phase peptide synthesis protocols were designed for its …

Although peptides are used as affinity chromatography ligands, they could be digested by
proteases. Usually, peptide stability is evaluated in solution, which differs from the resin …