ABSTRACT The conserved 3′‐5′ exoribonuclease EXOSC10/Rrp6 processes and
degrades RNA, regulates gene expression and participates in DNA double‐strand break …

Argonaute proteins, guided by small RNAs, play crucial roles in gene regulation and
genome protection through RNA interference (RNAi)-related mechanisms. Ribosomal RNAs …

Mutations in C10orf11 (oculocutaneous albinism type 7 [OCA7]) cause OCA, a disorder that
presents with hypopigmentation in skin, eyes, and hair. The OCA7 pathophysiology is …

Quality control requires discrimination between functional and aberrant species to
selectively target aberrant substrates for destruction. Nuclear RNA quality control in …

Eukaryotic ribosome biogenesis is an elaborate process during which ribosomal proteins
assemble with the pre-rRNA while it is being processed and folded. Hundreds of assembly …

In all domains of life, transfer (t) RNAs can be interrupted by intervening sequences (introns),
which must be removed by splicing to generate mature molecules required for protein …

RNA exosome is a multiprotein RNase involved in the modification of all RNAs in the cell; its
primary function includes exonucleolytic and endonucleolytic cleavage of pre-ribosomal …